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An increase in retrogressive thaw slump (RTS) activity has been observed in the Arctic in recent decades. However, a gap exists between observations in high Arctic polar desert regions where mean annual ground temperatures are as cold as -16.5 degrees C and vegetation coverage is sparse. In this study, we present a similar to 30 year record of annual RTS observations (frequency and distribution) from 1989 to 2018 within the Eureka Sound Lowlands, Ellesmere and Axel Heiberg Islands. Record summer warmth in 2011 and 2012 promoted rapid RTS initialization, increasing active slumps from 100 in a given year or less to over 200 regionally and promoting RTS initiation in previously unaffected terrain. Differential GPS and remote sensing observations of 12 RTSs initiated during this period (2011-2018) provided a mean headwall retreat rate for all RTSs of 6.2 m yr(-1) and for specific RTSs up to 26.7 m yr(-1). To better understand the dynamics of climate and terrain factors controlling RTS headwall retreat rates we explored RTS interactions by correlating headwall retreat with climate factors (thawing degree days, annual rainfall and annual snowfall) and terrain factors (aspect and slope). Our findings indicate a sensitivity of cold permafrost in the high Arctic to climate-driven thermokarst initiation, but the decoupling of RTS dynamics from climate appears to occur over time for individual RTS as terrain factors take on a greater role controlling headwall retreat. Detailed observations of thermokarst development in a high Arctic polar desert permafrost setting are important as it demonstrates the sensitivity of this system to changes in summer temperatures and highlight differences to changes occurring in other Arctic permafrost regions.