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In view of problems such as the poor control effect of combined sewage pollution caused by traditional intercepting weir and the limited extension of the urban drainage model, which needs a large amount of basic data, this paper not only studied the characteristics of mixed-flow pollution via the urban drainage model but also simulated and optimized 6 interception control strategies and proposed a water quality interception strategy based on the pollution concentration of combined sewage. The results showed that, compared with the traditional interception weir, the interception control strategy of rainwater discharge based on the mixed pipe network model can obviously improve the control rate of various pollutants and reduce the interception amount required for pollution control. Through optimization of the interception based on water quality control by the combination of chemical oxygen demand (COD) and NH4-N, the interception rate was improved by 10.9% to 56.1% in contrast to the traditional interception weir and the closure water volume was reduced by 1432-6154 m(3), which effectively improved the reliability and economy of the interception.