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The Kerio Valley basin in Kenya has undergone several periods of drought, yet drought patterns in the region are not well understood due to limited climatic data. Drought events in the region have resulted in crop failure and livestock deaths, exacerbating food shortages. In this study, the Standardized Precipitation Evapotranspiration Index (SPEI), a multi-scalar drought index was used to examine the onset, duration, severity, intensity, and frequency of agricultural and hydrological drought in the region. The gridded 0.5 degrees x 0.5 degrees climatic datasets from Climatic Research Unit for the period 1960-2016 was used for analysis. Temporal evolutions of SPEI at 6- and 12-month lags were subsequently used to evaluate agricultural and hydrological drought, respectively. Additionally, the Mann-Kendall trend test was used to test for trends in the time series. Results from the analysis show that: 1) droughts are becoming more frequent in the region, 2) drought intensities in the arid and semi-arid lands have weakened, 3) regions west of the Kerio River have recently recorded a wetting trend, and 4) the southern and central regions of the basin are drought-prone. Understanding the spatial and temporal patterns of drought in the basin can assist in drought preparation and mitigation planning.