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Climate change has adverse effects on agriculture, decreasing crop quality and productivity. This makes it necessary to implement adaptation and mitigation strategies that contribute to the maintenance of technical efficiency (TE). This study analyzed the relationship of TE with farmers' mitigation and adaptation action preferences, their risk and environmental attitudes, and their perception of climate change. Through the stochastic frontier method, TE levels were estimated for 370 farmers in Northwest Mexico. The results showed the average efficiency levels (57%) for three identified groups of farmers: High TE (15% of farmers), average TE (72%), and low TE (13%). Our results showed a relationship between two of the preferred adaptation actions against climate change estimated using the analytical hierarchy process (AHP) method. The most efficient farmers preferred change crops, while less efficient farmers preferred invest in irrigation infrastructure. The anthropocentric environmental attitude inferred from the New Ecological Paradigm (NEP) scale was related to the level of TE. Efficient farmers were those with an anthropocentric environmental attitude, compared to less efficient farmers, who exhibited an ecocentric attitude. The climate change issues were more perceived by moderately efficient farmers. These findings set out a roadmap for policy-makers to face climate change at the regional level.