This essay examines climatic and ontological change within the Anthropocene among the Makushi in Guyana. During fieldwork in the Makushi village of Surama, the author was frequently told how the wet and dry seasons have become irregular, the temperature has increased, and ecological changes have occurred in the forests and savannas. These perceived changes impact Makushi subsistence practices and have emerged concurrent with the local development of eco-tourism and increased interactions with outside entities in Surama. The author examines local ontological shifts related to these expanded interactions with outsiders, who advocate concepts of 'climate change', 'sustainability', and 'conservation'. Recent encounters with climate change and outside entities in Guyana provide an ethnographic case of the broader climatic and related changes occurring in Amazonia. This case is analysed herein through an ontological approach. Based on fieldwork data, the author examines how local transformations are situated within the greater dimensions of the Anthropocene.