globalchange  > 过去全球变化的重建
DOI: 10.1038/s41588-019-0425-8
WOS记录号: WOS:000473491900008
论文题名:
A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat
作者: Su, Zhenqi1,2; Bernardo, Amy3; Tian, Bin3; Chen, Hui1; Wang, Shan1; Ma, Hongxiang1,4; Cai, Shibin1,4; Liu, Dongtao1; Zhang, Dadong1; Li, Tao1,5; Trick, Harold3; St Amand, Paul6; Yu, Jianming7; Zhang, Zengyan8; Bai, Guihua1,6
通讯作者: Bai, Guihua
刊名: NATURE GENETICS
ISSN: 1061-4036
EISSN: 1546-1718
出版年: 2019
卷: 51, 期:7, 页码:1099-+
语种: 英语
WOS关键词: MARKER-ASSISTED SELECTION ; SCAB RESISTANCE ; DISEASE RESISTANCE ; FUNGAL PATHOGENS ; CLIMATE-CHANGE ; GENE ; QTL ; RNA ; SUSCEPTIBILITY ; POLYMORPHISM
WOS学科分类: Genetics & Heredity
WOS研究方向: Genetics & Heredity
英文摘要:

Fusarium head blight (FHB), which is mainly caused by Fusarium graminearum, is a destructive wheat disease that threatens global wheat production. Fhb1, a quantitative trait locus discovered in Chinese germplasm, provides the most stable and the largest effect on FHB resistance in wheat. Here we show that TaHRC, a gene that encodes a putative histidine-rich calcium-binding protein, is the key determinant of Fhb1-mediated resistance to FHB. We demonstrate that TaHRC encodes a nuclear protein conferring FHB susceptibility and that a deletion spanning the start codon of this gene results in FHB resistance. Identical sequences of the TaHRC-R allele in diverse accessions indicate that Fhb1 had a single origin, and phylogenetic and haplotype analyses suggest that the TaHRC-R allele most likely originated from a line carrying the Dahongpao haplotype. This discovery opens a new avenue to improve FHB resistance in wheat, and possibly in other cereal crops, by manipulating TaHRC sequence through bioengineering approaches.


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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/140772
Appears in Collections:过去全球变化的重建

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作者单位: 1.Kansas State Univ, Dept Agron, Manhattan, KS 66506 USA
2.Hebei Acad Agr & Forestry Sci, Inst Cereal & Oil Crops, Shijiazhuang, Hebei, Peoples R China
3.Kansas State Univ, Dept Plant Pathol, Throckmorton Hall, Manhattan, KS 66506 USA
4.Jiangsu Acad Agr Sci, Inst Food Crops, Nanjing, Jiangsu, Peoples R China
5.Yangzhou Univ, Coll Agr, Yangzhou, Jiangsu, Peoples R China
6.USDA ARS, Hard Winter Wheat Genet Res Unit, Manhattan, KS 66506 USA
7.Iowa State Univ, Dept Agron, Ames, IA USA
8.Chinese Acad Agr Sci, Crop Inst, Beijing, Peoples R China

Recommended Citation:
Su, Zhenqi,Bernardo, Amy,Tian, Bin,et al. A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat[J]. NATURE GENETICS,2019-01-01,51(7):1099-+
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