The construction industry consumes 40% of the global materials and produces one of the largest waste streams in the planet. In a circular economy, the reuse of building components in multiple life cycles aims at increasing resource efficiency and eliminating waste. But can reuse offset the environmental impacts of materials with high embodied energy (e.g. steel)? If so, in what conditions? In the study presented in this paper, the authors used two different life cycle assessment (LCA) methods to compare a single-use wood-framed wall against a reusable steel-framed wall in a tiny house in the U.S. The analyzed impact categories were global warming potential, embodied energy, and water use. One of the main goals of this study was to understand the benefits of reusing a material with high embodied energy when compared to a single-use alternative. Another equally important objective was to understand how different LCA methods can influence the results in a cradle-to-cradle (C2C) LCA. As results, reuse benefits depended on aggressive reuse rates (>70%) and multiple reuses of steel were needed to offset the embodied environmental impacts during steel production. Also, the analyses showed that process-based LCA and hybrid LCA can generate conflicting results in a C2C LCA. (C) 2019 Elsevier Ltd. All rights reserved.