globalchange  > 过去全球变化的重建
DOI: 10.1086/703178
WOS记录号: WOS:000467473700001
论文题名:
Cross Talk without Cross Tolerance: Effect of Rearing Temperature on the Hypoxia Response of Embryonic Zebrafish
作者: Levesque, Kelly D.; Wright, Patricia A.; Bernier, Nicholas J.
通讯作者: Bernier, Nicholas J.
刊名: PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
ISSN: 1522-2152
EISSN: 1537-5293
出版年: 2019
卷: 92, 期:4, 页码:349-364
语种: 英语
英文关键词: hypoxia-inducible factor-1 cellular pathway ; heat-shock proteins ; hypoxia tolerance ; temperature ; developmental stressors
WOS关键词: GENE-EXPRESSION ; HEAT ACCLIMATION ; WARM ACCLIMATION ; CLIMATE-CHANGE ; STRESS ; EXPOSURE ; CYTOPROTECTION ; ACTIVATION ; MUSCLE ; ENZYME
WOS学科分类: Physiology ; Zoology
WOS研究方向: Physiology ; Zoology
英文摘要:

Environmental stressors, such as warm temperatures and hypoxia, can interact and pose a threat to aquatic species. Cross talk between the hypoxia and heat stress cellular pathways can lead to enhanced cross tolerance between these environmental stressors. In this study, we questioned whether elevated temperatures (from 27 degrees to 32 degrees C) during rearing would enhance the hypoxia-inducible transcription factor-1 (HIF-1)-mediated transcriptional response to hypoxia (5% dissolved O-2) in early stages of zebrafish development and whether these differences would be associated with enhanced larval tolerance and survival to hypoxia. We found that embryos reared at 32 degrees C had an enhanced cellular HIF-1 response (elevated hif-1ab and insulin-like growth factor binding-protein mRNA level) and that acute hypoxia (4 h) activated the heat-shock response (elevated hsp70a and hsp90aa mRNA levels). Elevated rearing temperatures and hypoxia exposure also induced precocious hatching, but neither environmental stressor had an effect on the hypoxia tolerance (critical O-2 tension) of 4-d-old larvae and did not protect larvae against the lethal effects of a second acute hypoxia exposure. Overall, during early zebrafish development, cross talk between the hypoxia and heat stress cellular pathways at the gene expression level did not confer cross tolerance at the whole-animal level with respect to hypoxia stress.


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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/141076
Appears in Collections:过去全球变化的重建

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作者单位: Univ Guelph, Dept Integrat Biol, Guelph, ON N1G 2W1, Canada

Recommended Citation:
Levesque, Kelly D.,Wright, Patricia A.,Bernier, Nicholas J.. Cross Talk without Cross Tolerance: Effect of Rearing Temperature on the Hypoxia Response of Embryonic Zebrafish[J]. PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY,2019-01-01,92(4):349-364
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