In this paper, the impact of sea level rise (SLR) throughout the 21st century in the overtopping of port breakwaters is analyzed at a regional scale, focusing on the Catalan coast (NW Mediterranean). The study is made considering three scenarios of SLR and two levels of storminess, computing the overtopping discharges in 47 ports to assess those exceeding a tolerable threshold and to roughly estimate the monetary value of the consequences of such discharges. Possible adaptation measures are examined, selecting the most cost-effective and assessing the cost of its implementation for the different scenarios and two damage levels. Results show that, as it could be expected, the number of ports affected by overtopping will increase with SLR, as well as the economic impact. Another remarkable finding of this paper is the significant savings in adaptation measures achieved allowing a minimum level of damage in contrast to the zero-damage option.