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A severe drought has affected central Chile since 2009. Various adaptation responses have been developed, and a participatory process is required to learn from them. To enable this, a transdisciplinary approach was adopted to achieve two objectives: first, to test an approach for assessing the effectiveness of existing measures to respond to drought, specifically to distil strengths and weaknesses of implementation, and developing recommendations; second, to reflect on results from a pilot project conducted to ascertain its potential for scalability in terms of processes employed. The research was organized per the three types of knowledge needed to address complex problems through transdisciplinarity: systems, target and transformation knowledge. Using the recent drought as a boundary object, we conducted the pilot in two locations in Chile where we carried out literature reviews, interviews and focus group discussions were carried out. We identified adaptation measures at national and local scale, a set of which were evaluated applying the Index for the Usefulness of Adaptation Practices (IUPA). Results indicate that through IUPA, we could systematically account for the perceived effectiveness of applied measures. Strengths such as autonomy in the decision-making process emerged as key factors that could also be applied in other contexts, whereas weaknesses such as lack of integration with other policy domains, programs or projects were identified. To address weaknesses, key recommendations were proposed, which are congruent with context-specific expectations, capacities, experiences and knowledge, given that they were articulated by local actors. Results present empirical evidence on the important utility of transdisciplinary approaches in the evaluation of adaptation measures and can support the development of metrics related to adaptation process at the local scale.