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The effects of climate change are altering the environmental landscape of marine habitats and exposing organisms to stressful conditions that may exceed their tolerance limits. Marine intertidal organisms are well adapted to fluctuating environments by adjusting energy metabolism and inducing the cellular stress response (CSR). Recent studies have shown that food availability can influence stress tolerance of marine ectotherms where a well-fed organism is more "robust" and more likely to survive a stressor than an animal under a lowfood regime. We propose that the link between food availability and stress tolerance in marine ectotherms may be regulated by sirtuins, NAD(+)-dependent deacylases. In model organisms sirtuins act as energy sensors and are active under calorie restricted states where they target and regulate cellular metabolism, minimize oxidative stress, and influence the CSR. However, we know little regarding sirtuins in marine ectotherms. Herein we review the current literature on sirtuins in marine ectotherms including marine teleosts, limpets, and mussels. We show that the role of sirtuins in marine ectotherms is conserved from model organisms in regulating the CSR and energy, but the direct connection to NAD(+) status under fed and starved conditions requires more attention. Although there is a beginning foundation of research regarding sirtuins in marine organisms, it is limited and would benefit from targeted studies investigating sirtuin activity in various tissues and animals under multiple stressors, NAD(+)/NADH levels under various fed states, and by using known sirtuin inhibitors and activators to elucidate the potential targets of sirtuins in marine animals.