Discussion in the influencing factors of stromatolite decline would provide a great significance to the research of microbolites. The influencing factors of stromatolite decline are disputed. Now the influences of metazoan and microcosmic environment are focused,but weakening the role of global events weakens. During the geologic history,the global change regulates the atmosphere,biosphere and hydrosphere from the perspective of regional scale. It contains the increase of atmospheric oxygen amount, the supercontinent event, the " snowball" event and the biological outbreak and extinction. All these jointly work on a series of environment factors which are necessary for the stromatolite growth. In addition,stromatolite decline has a perfect time fitness and causal relationship with these global changes. During the different geologic time,global change with several different event combinations manages the rise and decline of stromatolite,by acting on the development of stromatolite biogenesis and the deposition rate of carbonatite selectively. By reviewing and summarizing literature data,the response relationship between stromatolite decline and global change is analyzed synthetically. It is the study that puts forward the important clues for future related research. Moreover,the tendency and key issues of stromatolite decline and global change for future research are touched upon.