Based on a series of international conferences for establishing HFA2 framework,this paper analyzed key issues of frontier of disaster risk science, integrated disaster prevention and mitigation strategies and integrated disaster risk governance. The future direction of disaster risk science was comprehensively discussed according to the widely discussed Post-2015 Hyogo Framework for Action (HFA2). It was proposed to deepen the cognition of the complexity of disaster system in terms of recognizing the complexity of disaster system from the interaction among various elements of the system,recognizing the complexity of climate change risk from the regional characteristics and formation mechanism of the global climate change and recognizing the complexity of the catastrophe risk from the regional development levels and patterns. Furthermore,it was suggested to make integrated disaster risk reduction strategies and countermeasures from the perspective of the complexity of the disaster system,including the establishment of regional integrated disaster risk governance framework to face climate change,the establishment of integrated disaster risk governance system in multi-spatial scale,the establishment of disaster risk governance financial system integrating the insurance,bonds and lottery,the establishment of consilience mode in integrated risk governance considering multi-stakeholder and the establishment of modeling and simulation platform integrated disaster risk information services and disaster risk reduction strategies. Finally, it was pointed out that the assessment of disaster risk levels for different regions in multi-spatial scale can provide robust scientific support for integrated disaster risk governance of the world and regions,industries and enterprises so as to improve response to global change and guarantee a global and regional sustainable development.