Glacier-snow melt water in the main form of surface runoff in the Hami region, Xinjiang, China. Affected by global climate warming, the glaciers in the Hami region are currently at the accelerating melt stage, and the shortage of water resources is the main restriction factor for social and economic development in the Hami region. In this study, the values of material balance, area and thickness of glaciers and the hydrological and meteorological data in the Hami region were measured and observed so as to predict the change trend of glacial hydrology and water resources, provide the references for further utilizing limited water resources, and work out the measures for the local sustainable development. The results revealed that the area and thickness of the glaciers in both Yushugou and Miaoergou valleys were in a slow reduction, a violent change of fluvial recharge will not occur in next decades, and such change trend will continue in the future.