Based on remote sensing (RS) and geographical information systems (GIS) techniques, glacier and lake change in Selin Co Basin was studied by Landsat TM, ETM + images in three different periods of 1990, 2000 and 2011. The trends of precipitation and temperature were analyzed for the period from 1966 to 2011 at three selected meteorological stations. The results indicate that the glaciers in the Selin Co Basin were decreased from 1990 to 2011 and the rate of retreat was accelerated after year 2000. It also shows that glacier melt rate in the south was faster than that in the north. The total area of lakes was increased. Area expansion of non - glacial - fed lakes was homogeneous throughout the whole study period. The expansion rate of glacial lakes was found much larger than the non - glacial - fed lakes and the rate of expansion was accelerated after year 2000 also. There was good coupling between the lake expansion and glaciers retreat. Different supply patterns determined different change trend of lake. Raised temperature and decreased precipitation in cold season were the main reasons for the glacier retreat, and the increased runoff from glaciers contributed to the extending of lakes. However, raised precipitation and decreased evaporation in the basin controlled the change of non - glacial - fed lakes.