In this paper, the methods of Theil-Sen and Mann-Kendall were used to calculate land degradation intensity and trend in Central Asia in the past 14 years based on SPOT - Vegetation remote sensing data. In combination with the elevation value, the impacts of human activities on land degradation were analyzed. The result shows that the city zone around two deserts (Kalakum desert and Kyzylkum desert) and the saline-alkali land in the west of Kazakhstan are regions suffering from most serious land degradation. The city zone around two deserts has excessively emphasized the development of economy and thus damaged the environment. And because of the natural conditions, saline-alkali land in the west of Kazakhstan has degraded significantly. Vegetation around the sea and lake, in the interior desert and in he region under the snow line has tended to increase, which coincides with previous studies of global warming and the tendency that the climate in Central Asia has gradually turned to warm wet. Climate change has caused ice melting. The regions which are not suitable for vegetation growth, such as the region in higher elevation and desert, are now growing vegetation. However, in these region, vegetation is largely desert vegetation, which can't be utilized and does not help promote economic development, thus of little significance to humans. On the whole, the human survival environment is still deteriorating. At the same time, vegetation around the deserts has increased a lot, which suggests that people have paid attention to the environmental problem and implemented some environmental engineering projects and windbreak and sand fixation projects.