Based on the global change history,tendency and its effect on multi-spheres of the earth,the global change process since the Cretaceous is summarized in this paper.It is concluded that the Tibetan Plateau is the engine of the global change and the heart of the hydrologic cycle over the eastern Asian.Quick drifting of climatic zone is the characteristics of today global change,and humid in the north China and arid in the south China will be the global change trend of China.The global change risk in the Western Route of Chinese South-to-North Water Transfer Project is prospected and it is considered that the water transfer project in interior of the Tibetan Plateau is not inter-drainage water transfer project but inter-source water transfer project and possibly generates global change,which is hard to overcome by human beings.Therefore,it is suggested to give up the project to avoid the potential risk.