High surface ozone concentration caused harm to human health and also could affect the plant growth. Ozone was a kind of important greenhouse gas and affected the global climate change. Based on the automatic continuous observation data of surface ozone concentration from June 1, 2010 to December 31, 2012 and July 1, 2010 to December 31, 2012 in the Taklimakan Desert hinterland and northern margin urban Korla, and combining with PM_(10) and meteorological data, the variation characteristics of surface ozone concentration at scales of day, week, month, season and the daily variation under different weather conditions were analyzed, the main factors affecting the ozone concentration variation were discussed too. Results showed that: (1) The daily variation of hourly mean ozone concentration was characterized by single peak with gentle changes during the night and dramatic changes during the day at Tazhong and Korla. The lowest concentration was at 09:00 and the highest was at 18:00. Comparing with other cities, the time delayed. (2) Ozone concentration variation has a weekend effect phenomenon. The weekly variation of ozone concentration decreased from Monday to Wednesday with the lowest in Wednesday, and increased after Thursday with the highest in Sunday. (3) The highest monthly average concentration was 89.6 mug·m~(-3) in June of 2010, and the lowest was 22.1 mug·m~(-3) in January of 2012 at Tazhong. And the highest monthly average concentration was 82.1 mug·m~(-3) in August of 2010, and the lowest was 12.5 mug·m~(-3) in December of 2012 at Korla. The ozone concentration reduced with June as the center every year. (4) Ozone concentration in spring and summer was higher than in autumn and winter. The variation trend agreed with other large and medium-sized cities. (5) Under four different kinds of weather conditions, the ozone concentration varied the most dramatically in sunny day, followed by in little rain day, and varied gently in cloudy day. The ozone concentration varied inconspicuously before sand weather, and dropped rapidly when sand weather beginning. (6) The daily variation of radiation was also characterized by single peak, and the variation was significantly earlier than the ozone concentration variation. The sun radiation intensity had a direct influence on the photochemical reaction speed, further, leading to the variation of ozone concentration. The daily variation of PM_(10) concentration was obvious contrary trend with the ozone concentration variation. The variation was significantly earlier than the PM_(10) concentration. (7) The daily average ozone concentration of clear day was higher than that it in slight rain day (snow day). The variation of near surface ozone concentration could also be affected by the meteorological factors such as temperature, relative humidity, wind speed, the direction of the wind and the sunshine hours. So many factors working together led to ozone pollution.