Coastal zone is the transition zone of marine ecosystem and land ecosystem. Coastal ecosystem is fragile and sensible to global climate change, and environmental pressure from economy development. Now, new pressure and environment questions come from the new marine economy development activities through all provinces along Chinese coastal. Marine ecology monitoring & regulation area (MEMRA) should to be adjusted according to the circumstances. MEMRA is the effective method of evaluating the pressure and environmental questions, the foundation of management based on marine ecosystem. MEMRA is an area for ecological protection and regulation, decided by marine ecology characteristics and environments questions,the regulation is provided by assessment of the ecological data from this area. In this paper, based on the theory of nature-human-society, eco-society and ecosystem service, discussing the concepts of marine ecology important area and MEMRA from nature and economy and society views. Based on management, ecology, and environmental questions, discussing the principles of MEMRA division. Based on marine ecosystem services, management factors, discussing 14 indices for MEMRA division, including natural environment indices, ecology indices, society and economy indices.