The weathering and spalling phenomenon is the most common disease of cultural relics. In order to examine the weathering regularity of sandstone under the change in seasonal climate,the temperature cycle test, dry /wet cycle test,temperature and dry /wet cycle test were carried out. The results indicate that the velocity of sandstone weathering speeds up with the increasing temperature but the effect of a single temperature cycle at room temperature on the speed of sandstone weathering is slow. Humidity has little effect on the rate of weathering at room temperature. However,under the effect of temperature and humidity,sandstone shows intensive weathering phenomena. There is a certain degree of weathering acting on sandstone in the climate change from year to year. The range in weathering with time will gradually become stable and regular.