Snow is an indicator of climate change,and its changes have a profound effect on the energy and radiation balance and water cycle. Thus,it is the best demonstration of regional response to study the relationship between snow and climate change. Temporal and spatial variation of snow depth, snow cover and snow line of Tibet Plateau and its response to climate change were examined using geostatistics and spatial analysis of GIS function based on MODIS snow cover from March 2000 to February 2011, snow depth daily data (passive microwave remote sensing) during 1979 ~2010,DEM and surface meteorological data. The results showed that the snow depth varied with regions and displayed high in the periphery and low in the middle of the study area. The mean snow depth increased significantly with a linear trend rate of 0. 26 cm/lOa during the period of 1979~1999 and decreased between 1999 and 2010. The regression analysis indicated that the number of pixels with increasing mean annual snow depth,accounted for 76. 9% of the total pixels in the study area,while only 23. 1 % for the opposite. The snow coverage generally decreasd between 2001 and 2010 with a linear trend rate of -38 900 km~2/10a in the Tibet Plateau. Large areas were still covered by snow all the year around in the Nyenchen Tanglha,the Himalayas,the Gangdise and Kunlun mountains,and parts of Plateau hinterland. The mean annual snow line tended to ascend slightly with a linear trend rate of 6. 54 m/lOa in Tibet Plateau. The mean snow line variation in autumn contributed to the mean annual one mostly. The value of snow line in Tibet Plateau increased slowly from the southeast to the northwest. The correlation analysis between snow parameters and climate factors indicated that the snow depth was mainly impacted by wind speed and sunshine hours in spring and autumn, precipitation in summer and wind speed in winter. Temperature is the main factor influencing on snow coverage for every season. In four seasons, temperature had more significant effect on snow cover than other factors. However, in spring and autumn,the snow line was positively and negatively related to temperature in spring and autumn respectively.