Based on life cycle assessment (LCA) and analytic hierarchy process (AHP), the integrated performance evaluation on the Environment-Resource-Economy of dimethyl ether from biomass (Bio-DME) was carried out. And four indexes of the system, i.e. environmental impact, resource consumption, economic cost and integrated performance, were obtained. The results indicate that, from global perspectives, the mainly environmental impact categories are global warming (GWP), acidification (AP) and photochemical ozone formation (POF), and the total of the three categories accounts for more than 95% of the total environmental impact. Also, the economic is the most significant factor affecting the integrated system performance, and about 56%-92% is derived from the economic. About 6% to 38% is derived due to the environmental impact, leading to it as the second significant factor. The effect of resource consumption on the system performance is weak, and it only accounts for 1% to 10% of the integrated performance. Reducing the collection radius can effectively lower the resource consumption and economic cost, but it has no obvious effect on the environment. It is suggested that the appropriate scale for the production of Bio-DME should be about 25 * 10~4 t/a.