Air quality is closely related to peoples health and lives. It is affected directly by the local emission of air pollutants and local meteorological factors. In this paper, based on observation data from Beijing, Tianjin and Shijiazhuang from 2001-2010, the relationships between the air pollution index (API) and meteorological factors were analyzed using correlation analysis and principal component regression. Assuming that air pollutant emissions are relatively stable, we discuss the potential impact of meteorological factors on air quality in the Beijing-Tianjin-Hebei region combining the simulation results of regional climate models. We found that air pressure, air temperature, precipitation and relative humidity are closely related to air quality. The API is positively related to air pressure and negatively related to other meteorological factors. The sea level pressure and air temperature of the Beijing-Tianjin-Hebei region will rise in the future according to regional climate modeling. Wind speed in the 21st century will decrease. Precipitation will decrease in the 2030s, but then the value of precipitation will rise and increase until the end of the 21st century. Relative humidity also has a rising trend, but it will decline in the 2030s and 2050s, then ascend. Under SRES A1B scenario, the future climate change has a certain effect on air quality improvement in Beijing-Tianjin-Hebei region. The future rangeability of API in Beijing is greater than Tianjin and Shijiazhuang. In the three cities, the peak values of API variation appear in June at all times.