Shihezi is located in Xinjiang,an arid area of Northwestern China. In the context of global warming, the dry-wet conditions of Shihezi have significantly influence on many aspects of production and life. Therefore, it is necessary to conduct the research to investigate the variation of past decades and predict change trend of dry-wet conditions in the future, so as to provide reference to relative research and farming operation management. Based on the daily temperature and precipitation data in Shihezi region from 1964 to 2012, the method of trend analysis,M-K analysis,wavelet analysis, relative humid index,and R/S analysis was applied to analyze the temporal characteristics in this area. The results showed that the annual temperature and precipitation had a significantly increasing trend. The relative humid of Shihezi region, summer and four stations increased while the relative humid of spring and autumn decreased in the past 49 years. Abrupt change occurred in the changing process of the relative humid index of annual change, spring,summer,autumn,Shihezi city,Mosuowan County and Paotai county while not occurred in Wulanwusu County. The relative humid index,annual and summer change in Shihezi region and in four stations, would transform form increasing trend to decreasing trend while transform form decreasing trend to increasing trend in spring and autumn. This paper can provide reference for the research of dry-wet conditions variation and response to meteorological drought efficiently.