Selection of ideal target site to establish the enhanced geothermal system (EGS) trial project in China has strategic significance to China in the process of energy conservation and coping with global climate change. Four types of target sites, namely plate tectonic activity, recent volcano, sedimentary basins and acidic rock areas are defined by their differential heat generation characteristics based on profile analysis using the national terrestrial heat flow map, Curie depth map, neotectonic map and acid rock distribution map. Eight indexes including heat flow, reservoir lithology, caprock thickness, Curie depth, tectonic stress, radioactive heat generation rate, temperature gradient and regional economics are used for establishing the target site evaluation system. Ten potential sites are evaluated comprehensively based on the index matrix system. The results show that Yangbajing, Yangjiang, Zhangzhou, Fuzhou could be the optimum target sites. Heat structure section analysis of two potential target sites was carried out to demonstrate the rationality of the matrix evaluation.