High temperature stress has serious influences on the yield and quality of corn. The yield loss would be devastating if heat injury happened at corn flowering stage. The Huang-Huai-Hai Plain is one of corn predominance regions in China, where high temperature damage often occurs in recent years. This study aims to explore the temporal and spatial distribution of the high temperature stress of corn at flowering stage in Huang-Huai-Hai Plain. Firstly, we determined hours per day of temperature higher than 34℃ at flowering stage as the index for heat injury, then we calculated the index value of each county in the Huang-Huai-Hai Plain during 2013, and analyzed its temporal and spatial distribution of the region. Secondly, based on the meteorological data in 63 a, we calculated the 2013 probability of high temperature stress at corn flowering stage in the region. The result shows that, Pingdingshan City, Xinyang City of Henan Province and area near by encountered unusual high temperature at flowering stage in 2013, where the probability of 2013 was below once-in-a-century. In order to reduce yield loss and overlapping time between the corn flowering stage and high temperature period, we suggested to sow about one week in advance for these areas. In background of the climate change, research on the temporal and spatial distribution of corn high temperature damage is significant to react the disaster mitigation of maize production.