In a view of regional response to global climate change, eustatic sea level variation and long-term trends of potential cycle in the Shanghai area are analyzed by using the grey model with linear regression analysis, which is combining the least square method and wavelet transform based on the yearly-averaged tidal data at the Wusong tide station in 1912-2000. The eustatic sea level rise in Shanghai area in 2030 is predicted as 4 cm compare with in 2011. Meanwhile, the relative sea level rise is predicted as 10-16 cm, which combined with eustatic sea level rise and published tectonic subsidence, urban ground subsidence, estuarine channel erosion resulted from the watershed soil and water conservation and large water conservancy engineering, and rising of water level due to the land reclamation and deep waterway regulation. Seven risks zoning of the sea level rise in land area of Shanghai is also estimated.