Climate change significantly affects the growth and nutrition accumulation of the rice. The objective of this research was to investigate the effects of CO_2 enrichment and warming on the content, accumulation and distribution of C and N in rice plant. The treatments included the enrichment of atmospheric CO_2 concentration up to 500 mumol/mol (CE), warming of canopy air with temperature increment of 2℃ (WA), and combined CO_2 enrichment and warming (CW) in comparison to ambient condition (CK). The results showed that: 1) CE treatment significantly decreased N concentration in rice plant and C and N distribution in rice spike, while elevated CO_2 significantly increased C concentration and C and N accumulation in rice plant. The treatment also increased C and N distribution in rice stems. 2)WA treatment significantly increased N concentration in rice plant and C concentration in the leaf at jointing stage and mature stage. Meanwhile, WA treatment significantly decreased C concentration in rice grain at flowing stage and mature stage. WA treatment significantly increased C accumulation at filling stage and flowing stage and also significantly increased N accumulation at jointing stage. WA treatment also increased C distribution in rice stems at flowing and filling stage and decreased C and N distribution in rice grain at mature stage. 3) CW treatment significantly increased C concentration, but significantly decreased N concentration in rice plant at filling stage. The treatment also decreased C and N distribution in rice grain, but increased the distribution in stems at mature stage.