To ease global warming, CO_2 emissions from large sources must be limited. The petroleum refining industry as one of the largest contributors to anthropogenic CO_2 emission is forced to implement CO_2 mitigation measures. At present,CO_2 separation from point source emissions has been recognized as one of several strategies necessary for mitigating unfettered release of greenhouse gases (GHGs) into the atmosphere. Therefore,the possible CO_2 separation technologies for end-of-pipe applications are briefly reviewed. According to the characteristics of flue gas from the refineries in China, three feasible CO_2 separation technologies are selected, such as the chemical absorption and membrane absorption methods for low concentration flue gas and pressure swing adsorption (PSA) for off gases of hydrogen manufacturing unit. Based on the current status of CO_2 emission from petroleum refineries in China, some suggestions are proposed as well.