Drought is one of the world's natural disasters of the widest influence and greatest loss for agriculture. Under the background of global change,drought risk has shown an increasing trend. Assessment and effective prevention on agricultural drought risk is an important measure to ensure food safety. With the help of EPIC model, assuming that the 0.5 degree grid is the average unit,wheat drought vulnerability curve of global mean grid is simulated by irrigation scenario method. Combining with the historical meteorological data,drought disaster causing factors of the global wheat are evaluated. Finally,yield loss risk of the global wheat causes by drought is calculated and the drought risk map of the global wheat is drawn up. Results show that: ① China,Russia and USA/ Hasikesitan are the first three countries in the risk ranking,risk index normalized are respectively 0.53,0.22 and 0.19; ② Spring wheat drought risk is higher than that of winter wheat. Based on the existing research on the evaluation of drought risk crops,taking into account the spatial resolution and accuracy of the vulnerability evaluation, wheat drought vulnerability curve consistent with spatial resolution of risk assessment is established,regional drought risk assessment is thus greatly enhanced,especially the accuracy of large scale.