The problem of vulnerability,sensitivity and adaptive capacity of ecosystem attracts more and more attention in the field of ecology and environment due to the global change and urbanization. Understanding the sensitivity degree of the ecological system to land use change is important to scientific and reasonable land use management.Taking one of the Central China Economic Zone-Anhui Province as an example,we constructed the mechanism of ecological sensitivity analysis to land use change under the vulnerability concept framework.By using the concept of elasticity,we established an ecological sensitivity index model.Finally,with the Land use change data of Anhui Province in 2002-2011,we studied the temporal and spatial regulation about the responsive degree of the ecosystem under the land use change of Anhui Province.The results show that:(1)From 2002 to 2013,the comprehensive land use intensity of Anhui Province increased from 2.26 to 2.49.Meanwhile,the ecological service value has decreased from 2 840 billion Yuan to 2 750 billion Yuan,and a strong negative correlation was observed between comprehensive land use intensity and the ecological service value.This correlation can also be found in the other 17 municipalities in Anhui Province.(2)In different periods,most areas in Anhui Province were insensitive or low sensitive,and only a few of areas had moderate sensitivity,severe sensitivity or extreme sensitivity.It suggested the present urbanization speed and intensity were not strongly influenced by the whole ecosystem of Anhui province.(3)From the spatial and temporal characteristics,there were 16 low sensitive or insensitive municipalities(92.97% of the total Anhui province area)in 2003 in Anhui Province, but it reduced to 12 municipalities(67.06% of the total Anhui province area)in 2011.Low sensitive and insensitive ares of Anhui Province has decreased,while sensitive areas has increased,and the extremely sensitive area has appeared.It indicates that the human activities have caused certain effect on the ecosystem.The results can provide scientific basis to adopt different modes of land use in different regions, and it will be helpful to achieve the sustainability of land use.