Based on previous disaster science researches, we assessed and regionalized meteorological disasters via GIS in order to identify the degree of meteorological disaster risk in tobacco-planting areas of western Hubei. The assessment process was composed of four subsystems including disaster inducing factors, disaster-forming environment, disaster-bearing body and the capability of natural disaster prevention and reduction. The results showed that the risk of meteorological disaster in the eastern areas is higher than the western areas in northwest Hubei. In southwest Hubei meteorological disaster risk is high in the south but low in the north. The vulnerability of tobacco planting is lower in southwest Hubei Badong and Enshi city and higher in northwest Hubei Zaoyang and Danjiangkou city. The meteorological risk in the north is lower than in the south of southwest Hubei. In northwest Hubei, meteorological risk is lower in southern regions and higher in eastern regions. Meteorological risk is the highest in some regions of Shennongjia and Hefeng, eastern Danjiangkou city. Overall, western Hubei is suitable for planting tobacco with risk levels at or below medium in most regions. Results from this study are important for planting reginaliation and production of tobacco.