As a consequence of global warming and water cycle enhancing,the climate change becomes most notable in Northwest China. Gansu Province is a significant ecological barrier in Northwest China. In this paper, daily temperature and precipitation data were collected from 46 meteorological stations in Gansu Province and surrounding areas. The spatial and temporal changes of climate were analyzed by means of linear trend,Mann- Kendall test after detecting data homogenization over Gansu Province for nearly 50 years. The results show that(1)average temperature,minimum temperature,maximum temperature,extreme maximum temperature,extreme minimum temperature were increasing significantly,especially,the minimum temperature rising was the most significant. Seasonal variation of air temperature was quite different from place to place. Seasonal minimum temperature and extreme minimum temperature risings were the most significant. Especially,spring and winter average minimum temperatures had increased outstandingly. In summer and autumn,the extreme minimum temperature rising was the most significant;(2)variation of precipitation in Gansu Province had regional difference, precipitation in east of Wushaoling had a decreasing trend and in west of Wushaoling had a increasing trend;the minimum precipitation tendency rate was over -22.2 mm·(10a)~(-1) and the maximum one was 14.1 mm·(10a)~(-1);(3)there was an abrupt change of air temperatures around 1986 in Hexi Region,earlier than that in Hedong Region(around 1993). According to the above analyses,spatial and temporal differences of climate change in Gansu Provinces were distinct and the Wushaoling has been a clear dividing line of the climate shift in the recent 50 years.