Wild population of Ranodon sibiricus continued to decline in China over the last decade,mainly because of dwindling wetlands for their survival, and this situation may be closely related to regional climatic change. For cognizing the potential climate-change effects on Ranodon sibiricus,the paper obtained the temperature and precipitation monthly data from 7 meteorological stations around the Xinjiang salamander nature reserve from 1963 to 2014,and utilized linear regression equation, accumulated anomaly method, Morlet wavelet function and non-parametric Mann-Kendall (M-K) test to analyze climatic characteristics of this large-scale area. The results suggest that annual mean temperature and precipitation of this region are in an upward trend over the past fifty years which consistent with the overall climatic changes of Xinjiang province. Temperature has a upward trend with the rate of 0.37 ℃ · (10 a)~(-1)(r= 0.632,P <0.001), which is higher than the conditions of the world and China in the same period. The significance in temperature increase since 1998, with warming of the four seasons as well, of which the winter temperature increase rate was the largest, which was as high as 0.47 ℃ · (10 a)~(-1) (r=0.338,P=0.014). The trend of precipitation went up at the rate of 13.32 mm· (10 a)~(-1) (r=0.349,P=0.011),increased significantly since 2002 (except 2008). Summer and winter precipitation made a major contribution, which growth tendency is 4.19 mm · (10 a)~(-1) (r=0.281,P=0.043) and 4.43mm·(10 a)~(-1) (r=0.443,P=0.001),respectively. Morlet wavelet analysis showed that regional temperature charactered 2,7-8 and 15-16 years of weak changing period, and regional precipitation had 5 and 13-14 years cycle, and the cyclical swing was obvious from 1980s to 1990s,but became unapparent in recent 15 years. Nearly a decade,increases of summer precipitation which was mainly consisted with liquid precipitation rather than solid precipitation, leading to reduced glacial accumulation, coupled with year-round warming effect, accelerated the speed of the Dzungarian Alatau Mountain high altitude glaciers liquefaction. With rapidly uplifting of glacier equilibrium line altitude, lowering of groundwater level in high altitude area, the reduced mountain springs led to the wetland is shrinking and wild Ranodon sibiricus population continue to decline.