Glacial lakes are important and the sensitive indicators of climate change. Mapping of these lakes and their spatiotemporal change is of a great importance to understand the alpine climate change and the change of glacial lakes related to hazards. In this paper, 12 time series of multi-source remote sensing images were used to map the change of glacial lakes in the Biezhentao Mountain and the west Tianshan Mountains,and the spatiotemporal change of the glacial lakes was analyzed from the sizes,elevations, slope aspects and lake types. Meteorological and glacier data were also used to discuss the driving forces of lake change. The results showed that the multi-temporal remote sensing data performed well in describing the temporal processes of lake change. Change of the glacial lakes in the Biezhentao Mountain could be divided into two different stages: the lakes shrank during the period of 1965-1978,but they expanded during the period of 1978-2014. Compared with other glacial lakes in the Himalayas, these glacial lakes are much smaller,and most of them are located in an elevation range of 3 300 ~ 3 500 m. Glacial lakes in this elevation range change fast,especially on the northern slope,which is consistent with the distribution of glaciers. There are 4 types of glacial lakes in the study area,and moraine lakes are the main type. Glacial lakes with glacier melting water supply, such as moraine lakes and cirque lakes,change more significantly than those including the erosion lakes and valley lakes without glacier melting. There was a good correlation between the meteorological data and the change of glacial lakes in the last 50 years,and the expansion or shrinkage of the glacial lakes responses to climate change from the dry-cold trend to the wet-warm one.