The Bayanbuluk alpine wetlands are located in an intermontane basin in the central Tianshan Mountains,Xinjiang,China. The hydrological cycle in the Bayanbuluk Basin is a complex process affected by climate, geographical features of the basin and human activities. In this study,the data from the Bayanbuluk Basin were analyzed to investigate the changes in annual runoff volume and precipitation during the period of 1960 - 2010. It was found that the annual runoff volume was in a significant increasing trend,the step change occurred in the year around 1993,and the long-term runoff series was divided into a natural period (1960 - 1993) and a human- induced period (1994 - 2010). The hydrologic sensitivity analysis method and water budget method were employed to evaluate the effects of climate change and human activities on mean annual runoff volume for the humaninduced period based on precipitation and potential evaporation. During the period of 1994 - 2010,climate change was the main factor causing the increase of runoff volume with a contribution rate of 66.52%,while the increasing proportion due to the increase of melt-water and human activities accounted for 21.28% and 12.2% respectively. In addition,the change of soil moisture content had an important effect on water resources.