Grain production is closely related to climate change. This article aims to analyze the effects of climate change on grain production and its regional differences based on input and output data and meteorological data of grain production across all country in 28 provinces(cities and districts) from 1984 to 2013. The results show that: 1) The impacts of both precipitation increase and temperature rise were positive. With the increase of precipitation per 100mm,the grain production increased by 0. 67% ~ 0. 85%. With the increase of temperature per 1℃,the grain yield increased by 0. 35% ~ 0. 41%. Meanwhile,the impacts of precipitation and temperature on grain production were significant and nonlinear. 2) The increase of precipitation and temperature rise inhibited the growth of grain production in south China,while promoted the grain yield on the northern region.