Using meteorological data from the east foot of Ningxia Helan Mountain during 1981 to 2015, and combing thresholds of some key climate resources of premium wine grapes from previous research results,we analyzed the change characteristics of precipitation,rainy days,diurnal range of temperature, water-heat coefficient and sunshine duration during harvest of wine grapes and their possible influences on wine grape quality. The results showed that the key climate resources had changed significantly in recent 35 years and an abrupt climate change occurred at the end of 1990s. After the abrupt climate change, the precipitation increased by 88%, and the possibility of precipitation ≥30 mm in September was 44%-71%, being 2.8-4.2 times as much as before. The possibility of precipitation ≥ 10 mm in the first ten days of September was 47%-65%, being 1.4-1.7 times as much as before. The rainy days increased by 55%-76%, and the frequency of lasting rain process (≥ 3 days) increased. The diurnal range of temperature decreased by 1.4 ℃, and the possibility of diurnal range of temperature ≤ 7.6 ℃ was 17%-22%, being 1.6 to 2.2 times as much as before. At the same time, water-heat coefficient increased by 0.26-0.37, with an increase rate of 60% -100%, and the possibilities ≥0.57 and ≥0.63 were 2.1-4.2 and 2.7-4.2 times as much as before, respectively. The sunshine duration decreased by 16%. The days of sunshine duration <6.5 h increased by 3.9-5.3 d, with an increase rate of 53%-78%. Therefore, the changes of key climate resources can decrease sugar content and increase acid content of wine grapes,thus decreasing the sugar/acid ratio and the content of tannins. In addition, these changes create favorable conditions for the occurrence of downy mildew and white rot of wine grapes.