Buha River is located in the northeast part of Qinghai-Tibet Plateau,which is the largest feeding river of Qinghai Lake. The basin of the river not only belongs to a typical eco-fragile region,but also is one of the most sensitive areas responding to the climate change. With the land-use transition matrix and the information variable analysis method for land-use,the law of the land-use transition of the river basin is studied herein along with the analysis made on the causations of the changes,so as to provide references for studying the runoff variation caused by the underlying surface changes under the scenario of the future climate changes within Qinghaihu Lake Basin. The result shows that the increments of the types of the land-use in the river basin from 1980 to 2014 mainly occur at the grasslands with high,medium and low grass-coverages,while the decrements mainly appear at the unused lands. Among the total variation,the absolute value of near half of it is quantitatively changed,and that the spatial location transition occurs for the other half. The net variations mainly occur at the grasslands with low grass-coverage and the unused lands,meanwhile,the alternating variations mainly appear at the gasslands with both the high and the medium grasscoverages. Moreover,the sptial transition analysis shows that the source area above El. 3 900 m at the northwest of the river basin belongs to a depopulated zone and is under the impact from the global climate change of temperature rise and precipitation increase with the obvious responding to the increase of the vegetation of the source area. However,the increasing types of the vegetation coverages are more dispersedly distributed in the area under El. 3 900 m,which is wholly under the impact from the natural factors of the climate changes,while a part of it is the concentrated distribution area of human and is under the larger impact from the human interferences,such as grazing,etc.,which belongs to the vegetation decreasing type.