We used the ratio threshold and visual interpretation to extract and analyze the glacier change and variation in the Bujiagangri region in the last 25 years based on Landsat data(TM/ETM+/OLI).Comparedto the variations of glacier in the four periods and its response to climate change,the result demonstrated that the glacial retreat was serious from 1988 to 2013 where 34.25km~2(18.67%)of glacier area had been retreated. In addition,the rates of glacier decline in 1988-1994-1999-2006-2013 appeared to be slowest,fastest, medium,and then faster,respectively.Generally,the volume of the glacier was decreased by 15.38%at the end of year 2013.The increase of temperature in the summer was likely to be the main reason for this phenomenon.Moreover,glacial change response was significant in the long-term climate change,while the short-term climate change was significant only in the overall trend of the glacier change.Generally,glaciers in the northern area declined quickly than that of the southern area due to the monsoon climate variations, the water vapor sources differences and variations in the scale and the elevation of the glacier areas.