【Objective】 The current and future distribution and stable suitable areas (i.e. low impact areas) were predicted for medicinal plant Fallopia multiflora (Thunb.) in China under climate change scenarios.【Method】 Maximum entropy model was employed to predict the geographic distribution of F.multiflora based on 138 occurrence records (1995-2000) and bioclimatic data (2020s-2080s).【Result】 ①The current suitable habitats of F.multiflora distributed in Sichuan,Chongqing,Shaanxi,Guangxi,Yunnan and Hubei.②The total area of current suitable habitats of F.multiflora was 205.38*10~4 km~2,accounting for 21.39% of China's land area.③53.86% of the current suitable habitats would be weakly impacted by climate change.④The areas of total and lowly suitable habitats would decrease significantly under climate change,that of moderately suitable habitats would remain stable,while that of highly suitable habitats would increase sharply.【Conclusion】 The negative effect of climate change upon F.multiflora was the shrinking of total suitable habitats.The predicted stable suitable area was 110.61*10~4 km~2,which can be regarded as candidate areas for standardized cultivation.Remaining current suitable habitats can be used as priority areas for field survey and collection of germplasm resource.