The climatic suitability distribution of flue-cured tobacco planting in Yunnan will be profoundly affected by climate change. According to three key factors influencing climatic suitability of flue-cured tobacco planting in Yunnan,namely,average temperature in July,sunshine duration from July to August,precipitation from April to September,the variations of climatic suitability distribution of flue-cured tobacco planting in Yunnan respectively in 1986 - 2005,2021 - 2040 and 2041-2060 under RCP4.5 and RCP8.5 climate scenarios were investigated by using the climatic simulation data in 1981-2060 and the meteorological observation data during 1986-2005. The results showed that climatic suitability region would expand northward and eastward and plantable area of flue-cured tobacco would gradually increase. The increment of plantable area was more in 2041- 2060 than in 2021-2040,and under RCP8.5 scenario than under RCP4.5 scenario. The optimum climatic area and sub-suitable climatic area were expanded considerably,while the suitable climatic area was not much changed. In the future,the north-central Yunnan such as Kunming,Qujing, Dali,Chuxiong,Lijiang would have a big increase in both the optimum climatic area and the cultivable area,meanwhile,the southern Yunnan including Wenshan,Honghe,Puer and Xishuangbanna would have a big decrease in both the optimum climatic area and the cultivable area.