Under the background of global climate change, the relationship between urban planning and climate change is becoming closer. For the establishment of urban planning systems, it is necessary to take the effects of climate change and the strategies of climate change adaptation into account. With developed countries and the world famous large cities as references, the successful experiences and practices of town's sustainable development for addressing climate change in the United States, Germany and Japan were summarized respectively. then, taking Shanghai as an example, the challenge of climate change faced by our large cities and their existing vulnerabilities in the process of urbanization were comparatively analyzed and summarized as follows: a insufficient consideration of the urban development planning and the compatibility of climate, an inadequate argument of the influence of the urbanization process on climate environment, a low standing ability of urban infrastructure against meteorological disasters and less attention to the impact of climate change on human health in cities and towns, etc. Lastly, several ideas or key directions of town's sustainable development in China for addressing climate change were put forward, including fully considering the capacity of regional climate and vigorously building ecological green ventilation gallery; Deeply carrying out the climate feasibility of the layout of urban functions and meteorological disaster risk assessment; Strengthening the urban climate change research and experiments, and constantly updating urban planning design parameters and standards; Enhancing the monitoring and early warning of life safety and body health for vulnerable groups and foreign resident population; Actively improving the mechanism for adaptation to climate change in the process of urbanization, etc., so as to offer reference for the preparation and application of urban development system in China.