The environmental changes due to the direct and indirect anthropogenic activities have tremendous effect on the ocean ecosystem.This has led to the non-reversible impact on the marine biological resource.Marine fishery including the fishing and aquaculture istwo major ways to make use of the marine biological resource.They provide high-quality protein and rare nutritional elements, which are indispensable to the food and nutrition security.The marine fishery production of China ranks the first in the world.It is not controversial that the inshore ecosystem of China is under the multiple environmental stressors derived from the over-exploration, the land-based pollution, and the global climate change.The government and the non-government organization abroad have put the first priority to study the impact of the changing environment on the ocean, marine fishery and the adaptation strategies have been made accordingly.Although China also paid a lot of attention to the marine environmental protection and the marine biological resource utility and protection, we still lag behind the advanced countries in both the basic research and the policy making.Generally, the changing environment under the global climate change may lead to the change of hydrological, physical, and the chemical prosperities of the ocean.Thechanging environment will influence the composition and the function of the ecosystem.Specifically, the marine diversity has decreased and the function and the productivity have degraded under the multiple stressors, which are all the major concerns of the fishery resource protection.As for the aquaculture organisms, the growth, the development, and the behavior are all impacted by the changing climate.A common phenomenon in the aquaculture is the mass mortality.Many abiotic and biotic factors are supposed to contribute to the mass mortality of the aquaculture organism.Notably, the virulence of the pathogen has changed under the changing climate.The impact of the climate change on fishery resources and the aquaculture are closely related.The former pays more attention on the dynamic evolution of the natural resources and the diversity protection, and the latter firstly is an issue of agriculture, mainly focusing on the physiological responseto the environmental stressors.Thus, the impact of the changing climate on marine fishery and the aquaculture is thelong-termand short-term adaption for the marine organism.The genome of the organism, which is the beginning and the result of the evolution, is the core of theresponse to the changingbecause the genomics provide not only global but also acute of analysis concerning the genome structure and function.The genetic diversity of the fishery resource wasderived from the mutation, geneticdrift, gene flow, natural aquaculture selection.The wide occurrence of the local adaptation of the marine organism suggests that the adaptive divergence cannot be ignored.The identification of the adaptive divergence, the intertidaladaption,and the adaptive mechanism by using the related species and populations are three priorities in the study of fishery resource protection for fine-grained genetic management of the important species.For the aquaculture organisms, more attention was put to the contemporary response to the stress environment.The high extreme temperature, the acidification, the hypoxia, the food shortage, the heavy metal, and the harmful alga are all the stressors we should be focused on at molecular, biochemical,organismal,and ecological level.In addition to the genetic composition, more attention should be paid on the phenotypic plasticity, because the physiological capacity is critical to the quick adaptation to the changing environment.For the better understanding of impact of the climate change on marine fishery resource and the aquaculture,the combination of multiple disciplines, the long term data accumulation, and the utility of the big data are required.