Wetlands are an important part of the land resource types. The change of wetland landscape pattern is closely related to climate change and land use change. In order to obtain the status and characteristics of the change of Hanjiang River Basin wetland resources, we analyzed the characteristics of the landscape change of Hanjiang River Basin wetland during 2000-2010 and scientifically diagnosed the status of wetlands to protect wetland resources based on the monitoring data of remote sensing satellite in 2000, 2005 and 2010. We used pressure-state-response model to collect indicators of ecological health status of Hanjiang River Basin wetland from three different angles and obtained weighting factors of evaluation index using AHP. We finally quantitatively evaluated ecological health status of different wetland regions of Hanjiang River basin as a whole based on fuzzy hierarchy comprehensive analysis model. The results showed that:(1) During the ten years, total area of wetlands of the Hanjiang River basin decreased, but the variation intensity of wetlands of Hanjiang River basin slowed down over time.(2) The ecological health of wetlands of Hanjiang River Basin has significant spatial differences. The trend of ecological health status was healthy in the northwest and fragile in southeast. Based on the results of fuzzy hierarchy comprehensive evaluation model, ecological health of wetlands of upper reaches of Hanjiang River Basin was good while that of middle reaches of Hanjiang River Basin was sub-healthy and that of downstream of Hanjiang River Basin was fragile. The overall ecological health status of wetland landscapes of Hanjiang River Basin was sub-healthy.