Lop Nur is located in the northeastern area of the Tarim Basin,Xinjiang Uygur Autonomous Region, Northwestern China. A 2.2-m-deep trench profile has been taken in the center of the Lop Nur and named DHX (40°07'40.18N,90°28'51.77E). The chronology of the section was determined based on AMS ~(14)C dating. Element,grain size,total organic matter (TOC),C/N (total organic matter/total organic nitrogen) were used to reconstruct the environmental sequence and climate events from the Late Glacial to Middle Holocene. The environmental changes in the Lop Nur region can be divided into five stages based on significant changes in the multi-proxy assemblages. During Late Glacial (12.8~11.4cal.ka B.P.) the values of grain size components Md, C1,C2 and C3 were low which demonstrate a low water dynamistic. The low TOC and C/N values indicate a little amount of organic material from sediment basin. The highest Rb/Sr value show physical weathering dominates this stage. The high Fe/Mn values together with low Mg/Ca indicate cold climate and low lake level. The multi-proxy indicates dry climate dominates this stage. May be the ITCZ (intertropical convergence zone) location more south and low insolation triggered low snow and ice melt or precipitation in the mountains. From 11.4cal.ka B.P. to 9.6cal.ka B.P.,the Rb/Sr value decrease which demonstrates the chemical weathering dominates this stage. TOC and C/N values increase show more organic material from sediment basin. The low Fe/Mn values together with high Mg/Ca show temperatures increasing and wet climate appear in Early Holocene. This warm wet stage may caused by insolation values high in summer and low in winter and the ITCZ move north induced deglaciation. During 9.6~ 8.2cal.ka B.P. the obviously fluctuation of Fe/Mn, Mg/Ca and TOC values may be triggered by fluctuation of the ITCZ position. Between 8.2~6.7cal.ka B.P. warm wet climate appear. Chemical weathering still dominates this stage. May be the warm wet climate controlled by strengthening of monsoon and the north migration of ITCZ. From 6.7cal.ka B.P. to 5.5cal.ka B.P. grain size and Fe/Mn values are increased, coincident with decreased of Rb/Sr, Mg/Ca, TOC and C/N values and climate became dry. Decreased summer temperatures induce low snow and ice melt or precipitation in the mountains,and increased winter temperatures triggered more evaporation. The south migration of ITCZ triggered the dry climate. Climate events such as the dry event at ca. 11.Ocal.ka B.P., 10.0cal.ka B.P.,9.3cal.ka B.P.,8.4cal.ka B.P., 7. Ocal.ka B.P., and 5.8~5.5cal.ka B.P. were recorded in the Lop Nur section. Dry event co-occurring with the weakening of monsoon,the south migration of ITCZ and the cooling event of Greenland ice and North Atlantic. The evidence demonstrates that climate oscillations in the Lop Nur area were influenced and controlled by changes in global climate.