Whether the climate is humid in Early-Middle or in Middle Holocene still remains a question in East Asian monsoonal regions. Meanwhile, the Holocene climate instability has become one of the research hotspot. The middle-east part of Inner Mongolia is located in the transitional zone between East Asian monsoon and Westerlies, which is sensitive to the monsoon intensity and global climate change. A continuous 3-m sediment profile was recovered from Chagan-Nuur in middle-east part of Inner Mongolia (43°25'49"N,114°57'26"E; 1008m a.s.l.). Radiocarbon ages on bulk organic carbon and charcoal determined by accelerator mass spectrometry (AMS) are used to establish the chronology of the profile. Loss on ignition, grain-size and its end-member analysis of the profile were used to infer climate conditions. The increase of clay content, EM1, and LOI 550 values, and the decrease of median diameter, indicate relatively humid climate, and vice versa. Thus we reconstructed the climate changes in the middle-east part of Inner Mongolia during the last 7000 years. The results show that, on the millennial scale, the climate in the study area is gradually drying up in recent 7000 years,which is related to the weakening of East Asian monsoon produced by gradually reducing of solar radiation. However, the climate is relative wet during the periods of 6900~5800cal.a B.P. and 4500~2000cal.a B.P., while the climate is dry during the periods of 5800~ 4500cal.a B.P. and 2000~0cal.a B.P. On the centennial scale, Chagan-Nuur has experienced five obvious drought events, which occurred during 5800 ~4700cal.a B.P.,3500~3100cal.a B.P.,2600 ~2100cal.a B.P.,1700 ~ 1200cal.a B.P. and 560~370cal.a B.P. These drought events, within the dating errors, are consistent with the solar activity weakening events and the North Atlantic ice rafting events,showing that East Asian monsoon intensity on centennial scale is probably affected by the high latitude climate and the solar activities.