In this paper,the evolution and driving forces of water consumption structure in the Manas River Basin were analyzed using the related statistical data during the period of 2000 - 2013 based on the information entropy theory. The water consumption system in the drainage basin was divided into the farming,industrial and domestic water consumption subsystems. According to the characteristics of the water consumption subsystems,the correlation degrees of industrial,farming and domestic water consumptions were quantified with the gray correlation analysis. The results showed that the farming water consumption was slowly reduced,but its proportion was still high; the industrial and domestic water consumptions were increased. Because of the influence of single water consumption subsystems,the increase of information entropy of water consumption structure was slow,and the balance degree of water consumption was low. The results of correlation degrees revealed that climate warming,increase of ET_0 and soil salinization or alkalization were the internal driving forces resulting in the high proportion of farming water consumption in the drainage basin,and the external driving factors resulting in the increase of water consumption were the irrigation area,cotton sown area,value of industrial output,increase of the proportion of heavy industry and urbanization. It was considered that the main measures for relieving the supply-demand imbalance of water resources were to popularize water-saving irrigation,enlarge the water-saving irrigation area and promote the efficiency of industrial water consumption.