Trans-1-chloro-3,3,3-trifluoropropene [HCFO-1233zd(E)] has virtually zero ozone depletion potential(ODP,0.00024)and very low global warming potential(GWP,7),and therefore it has been proposed as the fourth-generation blowing agent to replace 1,1-dichloro-1-fluoroethane(HCFC-141b) and 1,1,1,3,3-pentafluoropropane(HFC-245fa),due to its very low impact for environment. Synthetic methods of HCFO-1233zd(E) were summarized according to the starting materials. Compared with other routes,the process using HCC-240fa and its derivatives as starting material features good yield and excellent selectivity,and thus has an industrialization prospect. Moreover,the azeotropic separation of HCFO-1233zd(E) with HF and by-product in the preparation process was analyzed and summarized. Developing efficient fluorination catalyst and environmentally friendly purification technology is fundamentally important for industrial synthesis of HCFO-1233zd(E).