Typical meteorological year (TMY)data were generated using two methods, i.e., Sandia and Danish methods. The load of a typical office building in Tianjin was simulated by the TRNSYS software based on the meteorological year data. The results showed that both Sandia and Danish methods can be well used to generate TMY in Tianjin. The TMY data were obviously changed under the conditions of climate change, and the impact of climate change in the heating period (November-March)was more obvious than that in the cooling period (June- September). Compared to the heating load during 1961-1990, the building heating load of 1981-2010 decreased by 5.2%, while the building cooling load increased by 1.6%. Therefore, the impact of climate change should be fully considered in the process of evaluating energy consumption of building design by using the TMY data. The generation and updating of TMY data should be quickly made. Compared to the cooling load during 1981-2010, the simulated building cooling load based on present TMY data decreased by 6.7%, while the building heating load increased by 4.7%. This shows building energy consumption estimation by using present TMY data in Tianjin may overestimate heating load but underestimate cooling load. Thus, it may decrease the body comfort of indoor environment and lead to waste of heating energy.